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Microdose LSD: Does It Make You Smarter?

Microdosing takes place when a person consumes small quantities of mind-altering substances. The goal of doing it is to improve thought processes without affecting your body the same way a recreational dose would.The practice has become a growing trend–with advocates all over the world saying there are many benefits to doing it.

Meanwhile, devotees are saying that taking crumb-sized dosages of LSD enhances brain performance. This drug of choice is definitely in for certain circles within the Silicon Valley crowd, too,who avidly swear by its effectiveness as a neuro-enhancer. In fact, there is enough buzz around the technique to spawn anew generation of microdosing coaches and consultants, along with their self-help books.

Likewise, entire industries such as Paul F.Austin’s Third Wave are centered on the purported benefits that popping minuscule amounts of acid provide.These psychonauts all say that doing it will revolutionize your life. However,does microdosing LSD really make you smarter or can we just chalk it up to savvy marketing?

Psychedelics Have Proven Benefits

Hallucinogens reigned supreme during the 50s and 60s, and they are having a bit of resurgence due to the public’s softening attitude on drugs. Research drugs such as magic mushrooms received an acknowledgment as a potential anti-depressant by the US Food and Drug Administration (FDA), and some states are making major pushes for decriminalization of the substance, commonly known as ‘shrooms.

One hallucinogen that has proven therapeutic benefits,and is available for use today is used in Spravato nasal spray. Available since 2019, Spravato contains esketamine, which is ketamine in hydrochloride form. Spravato is used together with an oral antidepressant to treat depression in adults resistant to conventional

Promising LSD Microdosing Studies

Research that brought Spravato to fruition, much like other numerous clinical studies on psychoactive substances, focuses on full doses –say close to what you would get from a full recreational dose. There aren’t many studies surrounding microdosing today, and much of what we know about their effects and benefits are based on the collective experience the micro dosing community has reported(anecdotal evidence). Until recently, the effects of sub threshold doses of LSD had not been tested in a controlled laboratory setting.

One clinical study on microdosing conducted by the Beckley Foundation in 2019 looked at its potential for therapeutic applications. In the study, they investigated the temporary effects of differing amounts of small doses of LSD and then tracked how the doses influenced participant’s mood, pain tolerance and cognitive functions. At the end of the study, the researchers said the results were groundbreaking, even having implications for the treatment of Alzheimer’s disease.

The results were so promising that the Beckley/Maastricht Programme announced they would be conducting future studies.


Second Study Finds Few Benefits

The University of Chicago Department of Psychiatry and Behavioural Neuroscience published an article about their 2019 study, which was the first double-blind and placebo-controlled study of its kind ever conducted on LSD microdosing.

At the end of the study, the article states that, despite all the anecdotal evidence,researchers found that taking minuscule amounts of acid doesn’t do much more than make you a little high.That research,led by University of Chicago professor Dr. Harriet DeWitt,was conducted in the same year (2019) that the Beckley Foundation study took place.

The researchers in the Chicago study said that acid produced subjective effects across doses of 61/2, 13, and 26 μg. At the highest dose, this research chemical increased vigor and slightly decreased positivity ratings in subjects who were presented pictures with positive emotional themes. They also said that other mood and physiological measures, along with cognition were unaffected.

Why the Big Disparity?

Of the University of Chicago study, one of the conclusions was that a threshold dose of 13 μg of LSD might be used safely when investigating repeated administrations.They also said that “it remains to be determined whether the drug improves mood or cognition in individuals with symptoms of depression.” The results fly in the face of the Beckley Foundation’s studies, so why the big disparity?
The researchers wrote that the increased connectivity between the different regions of the brain that LSD causes during microdosing may lead to people evaluating “emotionally charged phenomenon” differently than they normally would. They also wrote,”One possible explanation for our results is that LSD reportedly enhances global connectivity in the brain, giving rise to the phenomenon of ego dissolution,or a weakening of the boundary between the self and the universe.”

The Answer May Lie in Reality

Professor DeWitt told PsyPost that the study might not accurately show how people are microdosing LSD in the real world. She explained that “the new study only represents the first step into research on microdosing LSD. Most people who microdose LSD do so on a frequent —sometimes daily —basis. Future research should examine whether the beneficial effects emerge only after repeated administration.”

De Wit also said that it is possible that microdosing lysergic acid diethylamide may have different effects on patients struggling with mental health issues. She added that “this type of study may improve our understanding of the psychological and neural processes that underlie negative mood states and depression. We are seeking support to fund additional studies.

So...What’s the Final Answer?

If you go solely on clinical studies, the jury is still out on whether microdosing acid is going to make you smarter, happier…. or anything other than a little giddy. The final answer is undetermined at present, but keep in mind that the decision-makers of both the studies found the results promising enough to warrant future research. So,the old saying of “where there’s smoke there’s fire”might apply here.
For now, we only have the subjective opinion of the microdosing community who say that taking teeny tiny doses of LSD makes them more intelligent. On the other hand, if tens of thousands of the microdosing community and psychonauts attest to its neuro-enhancing properties and more, you can figure there’s probably something to it. Be sure to keep your eyes on breaking news about future research on the subject, psychonauts, because things are about to get pretty interesting.



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